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| カタログ番号 | HC066023 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Human FZD3/Frizzled-3 Nanobody (SAA2319) [SAA2319] (HC066023) is a human monoclonal antibody detecting Frizzled-3 in ELISA. Suitable for Human.
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| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-Fc | ||||
| クローンID | SAA2319 | ||||
| ターゲット | Frizzled-3, Fz-3, hFz3, FZD3 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9NPG1 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Frizzled-3 (FZD3) is a ~76 kDa protein. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. | ||||
| 注意事項 | For research use only |
SDS-PAGE for Anti-Human FZD3/Frizzled-3 Nanobody (SAA2319)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
