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| カタログ番号 | HF008014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GABARAP Polyclonal Antibody (HF008014) is a rabbit polyclonal antibody detecting GABARAP in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cavia porcellus.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GABARAP (Met1-Leu117). | ||||||||
| ターゲット | MM46, GABA(A) receptor-associated protein, GABARAP, Gamma-aminobutyric acid receptor-associated protein, FLC3B | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95166 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Gamma-aminobutyric acid receptor-associated protein (GABARAP) is a ~13 kDa protein. Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. 1. Wang, H. et al. (1999) Nature 397, 69-72. PMID: 9892355 2. Kabeya, Y. et al. (2004) Journal of cell science 117, 2805-12. PMID: 15169837 3. Behrends, C. et al. (2010) Nature 466, 68-76. PMID: 20562859 4. Colecchia, D. et al. (2012) Autophagy 8, 1724-40. PMID: 22948227 5. Chino, H. et al. (2019) Molecular cell 74, 909-921.e6. PMID: 31006538 6. Genau, HM. et al. (2015) Molecular cell 57, 995-1010. PMID: 25684205 7. Lee, JH. et al. (2005) Biotechnology letters 27, 623-8. PMID: 15977068 | ||||||||
| 注意事項 | For research use only. |
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