Anti-Human GABBR2 Polyclonal Antibody (HF750014)

Name: Anti-Human GABBR2 Polyclonal Antibody
Brand: abinScience
SKU: HF750014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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SDS

Aperçu

Numéro de catalogue

HF750014

Description

Anti-Human GABBR2 Polyclonal Antibody (HF750014) is a rabbit polyclonal antibody detecting GABBR2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human GABBR2 (Ser57-Lys467).

Cible

Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B

Purification

Purified by antigen affinity column.

Numéro d'accès

O75899

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) is a ~105 kDa protein. Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission.

1. Villemure, JF. et al. (2005) The Biochemical journal 388, 47-55. PMID: 15617512

2. Nomura, R. et al. (2008) The Journal of biological chemistry 283, 4665-73. PMID: 18165688

3. Geng, Y. et al. (2012) Nature neuroscience 15, 970-8. PMID: 22660477

4. Geng, Y. et al. (2013) Nature 504, 254-9. PMID: 24305054

5. White, JH. et al. (1998) Nature 396, 679-82. PMID: 9872316

6. Kuner, R. et al. (1999) Science (New York, N.Y.) 283, 74-7. PMID: 9872744

7. Ng, GY. et al. (1999) The Journal of biological chemistry 274, 7607-10. PMID: 10075644

8. Sullivan, R. et al. (2000) The Journal of pharmacology and experimental therapeutics 293, 460-7. PMID: 10773016

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human GABBR2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human GABBR2 Polyclonal Antibody (HF750014)

Aperçu

Images

Reférences

Fiche technique

SDS