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| カタログ番号 | HF750014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GABBR2 Polyclonal Antibody (HF750014) is a rabbit polyclonal antibody detecting GABBR2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GABBR2 (Ser57-Lys467). | ||||||||
| ターゲット | Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75899 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) is a ~105 kDa protein. Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. 1. Villemure, JF. et al. (2005) The Biochemical journal 388, 47-55. PMID: 15617512 2. Nomura, R. et al. (2008) The Journal of biological chemistry 283, 4665-73. PMID: 18165688 3. Geng, Y. et al. (2012) Nature neuroscience 15, 970-8. PMID: 22660477 4. Geng, Y. et al. (2013) Nature 504, 254-9. PMID: 24305054 5. White, JH. et al. (1998) Nature 396, 679-82. PMID: 9872316 6. Kuner, R. et al. (1999) Science (New York, N.Y.) 283, 74-7. PMID: 9872744 7. Ng, GY. et al. (1999) The Journal of biological chemistry 274, 7607-10. PMID: 10075644 8. Sullivan, R. et al. (2000) The Journal of pharmacology and experimental therapeutics 293, 460-7. PMID: 10773016 | ||||||||
| 注意事項 | For research use only. |
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