中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY292013 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Human GBA Nanobody (SAA2277) [SAA2277] (HY292013) is a alpaca monoclonal antibody detecting Human GBA in ELISA, BLI. Suitable for Human.
|
||||
| 種反応性 | Human | ||||
| アプリケーション | ELISA, BLI | ||||
| 宿主種 | Alpaca | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-His | ||||
| クローンID | SAA2277 | ||||
| ターゲット | Lysosomal acid glucosylceramidase, Lysosomal acid GCase, EC:3.2.1.45, Acid beta-glucosidase, Alglucerase, Beta-glucocerebrosidase, Beta-GC, Beta-glucosylceramidase 1, Cholesterol glucosyltransferase, SGTase, EC:2.4.1.-, Cholesteryl-beta-glucosidase, EC:3.2.1.-, D-glucosyl-N-acylsphingosine glucohydrolase, Glucosylceramidase beta 1, Imiglucerase, Lysosomal cholesterol glycosyltransferase, Lysosomal galactosylceramidase, EC:3.2.1.46, Lysosomal glycosylceramidase, GBA1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >90% as determined by SDS-PAGE. | ||||
| 精製 | Purified by Nickel column. | ||||
| アクセッション番号 | P04062 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||
| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Lysosomal acid glucosylceramidase (GBA) is a ~59 kDa protein. Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). 1. Ron, I. et al. (2005) Blood cells, molecules & diseases 35, 57-65. PMID: 15916907 2. Akiyama, H. et al. (2013) Biochemical and biophysical research communications 441, 838-43. PMID: 24211208 3. Akiyama, H. et al. (2020) The Journal of biological chemistry 295, 5257-5277. PMID: 32144204 4. Bannink, S. et al. (2024) Journal of lipid research 65, 100670. PMID: 39395789 5. Vaccaro, AM. et al. (1997) The Journal of biological chemistry 272, 16862-7. PMID: 9201993 6. Magalhaes, J. et al. (2016) Human molecular genetics 25, 3432-3445. PMID: 27378698 7. Kitatani, K. et al. (2009) The Journal of biological chemistry 284, 12972-8. PMID: 19279011 8. Marques, AR. et al. (2016) Journal of lipid research 57, 451-63. PMID: 26724485 9. Boer, DE. et al. (2021) Journal of lipid research 62, 100018. PMID: 33361282 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human GBA Nanobody (SAA2277)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
