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| カタログ番号 | HW478014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GBP2 Polyclonal Antibody (HW478014) is a rabbit polyclonal antibody detecting GBP2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GBP2 (Thr35-Asn276). | ||||||||
| ターゲット | Guanylate-binding protein 2, EC:3.6.5.-, GTP-binding protein 2, GBP-2, HuGBP-2, Guanine nucleotide-binding protein 2, Interferon-induced guanylate-binding protein 2, GBP2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P32456 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Guanylate-binding protein 2 (GBP2) is a ~67 kDa protein. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. 1. Braun, E. et al. (2019) Cell reports 27, 2092-2104.e10. PMID: 31091448 2. Neun, R. et al. (1996) FEBS letters 390, 69-72. PMID: 8706832 | ||||||||
| 注意事項 | For research use only |
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