Anti-Human GBP5 Polyclonal Antibody (HP723014)

Name: Anti-Human GBP5 Polyclonal Antibody
Brand: abinScience
SKU: HP723014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HP723014

Description

Anti-Human GBP5 Polyclonal Antibody (HP723014) is a rabbit polyclonal antibody detecting GBP5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human GBP5 (Met1-Gly305).

Cible

GBP5, GBP-TA antigen, GTP-binding protein 5, Guanine nucleotide-binding protein 5, GBP-5, Guanylate-binding protein 5

Purification

Purified by antigen affinity column.

Numéro d'accès

Q96PP8

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Guanylate-binding protein 5 (GBP5) is a ~66 kDa protein. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome.

1. Wehner, M. et al. (2010) The FEBS journal 277, 1597-605. PMID: 20180847

2. Shenoy, AR. et al. (2012) Science (New York, N.Y.) 336, 481-5. PMID: 22461501

3. Krapp, C. et al. (2016) Cell host & microbe 19, 504-14. PMID: 26996307

4. Braun, E. et al. (2019) Cell reports 27, 2092-2104.e10. PMID: 31091448

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human GBP5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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