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| カタログ番号 | HP723014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GBP5 Polyclonal Antibody (HP723014) is a rabbit polyclonal antibody detecting GBP5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GBP5 (Met1-Gly305). | ||||||||
| ターゲット | GBP5, GBP-TA antigen, GTP-binding protein 5, Guanine nucleotide-binding protein 5, GBP-5, Guanylate-binding protein 5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96PP8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Guanylate-binding protein 5 (GBP5) is a ~66 kDa protein. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. 1. Wehner, M. et al. (2010) The FEBS journal 277, 1597-605. PMID: 20180847 2. Shenoy, AR. et al. (2012) Science (New York, N.Y.) 336, 481-5. PMID: 22461501 3. Krapp, C. et al. (2016) Cell host & microbe 19, 504-14. PMID: 26996307 4. Braun, E. et al. (2019) Cell reports 27, 2092-2104.e10. PMID: 31091448 | ||||||||
| 注意事項 | For research use only. |
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