Anti-Human Glucagon R/GCGR Recombinant Antibody (SAA0132), APC (HW547137)

Name: Anti-Human Glucagon R/GCGR Recombinant Antibody (SAA0132), APC
Brand: abinScience
SKU: HW547137
Price: 290 USD
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Número de catálogo	HW547137
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG2, kappa
ID de clon	SAA0132
Conjugación	APC
Objetivo	GCGR, Glucagon receptor, GL-R
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), APC
Número de acceso	P47871
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Glucagon receptor (GCGR) is a ~54 kDa protein. G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. 1. Qiao, A. et al. (2020) Science (New York, N.Y.) 367, 1346-1352. PMID: 32193322 2. Cong, Z. et al. (2024) Cell discovery 10, 18. PMID: 38346960
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.