

| カタログ番号 | HF869137 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | SAA0430 |
| 抱合 | APC |
| ターゲット | GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC |
| アクセッション番号 | O95390 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Growth/differentiation factor 11 (GDF11/BMP11) is a ~45 kDa protein. Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. 1. Cox, TC. et al. (2019) Human mutation 40, 1813-1825. PMID: 31215115 2. Walker, RG. et al. (2017) BMC biology 15, 19. PMID: 28257634 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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