

| Каталожный номер | HD415014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human GEMIN2 Polyclonal Antibody (HD415014) is a rabbit polyclonal antibody detecting GEMIN2. Suitable for Human, Mouse, and Rat.
Highlights
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| Реактивность видов | Human, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human GEMIN2 (Thr99-Ser280). | ||||||||
| Цель | Component of gems 2, GEMIN2, Gem-associated protein 2, Gemin-2, SIP1, SMN-interacting protein 1, Survival of motor neuron protein-interacting protein 1 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O14893 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Gem-associated protein 2 (GEMIN2) is a ~31 kDa protein. The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. 1. Chari, A. et al. (2008) Cell 135, 497-509. PMID: 18984161 2. Liu, Q. et al. (1997) Cell 90, 1013-21. PMID: 9323129 3. Yi, H. et al. (2020) Nucleic acids research 48, 895-911. PMID: 31799625 4. Golembe, TJ. et al. (2005) Molecular and cellular biology 25, 10989-1004. PMID: 16314521 5. Zhang, R. et al. (2011) Cell 146, 384-95. PMID: 21816274 | ||||||||
| Примечание | For research use only |
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