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| カタログ番号 | HT385014 | ||||||||
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| 説明 |
Anti-Human GET3 Polyclonal Antibody (HT385014) is a rabbit polyclonal antibody detecting GET3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GET3 (Ser36-Gln348). | ||||||||
| ターゲット | Arsenite-stimulated ATPase, TRC40, ATPase GET3, hASNA-I, Arsenical pump-driving ATPase, hARSA-I, GET3, ARSA, ASNA1, Guided entry of tail-anchored proteins factor 3, ATPase, Transmembrane domain recognition complex 40 kDa ATPase subunit | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43681 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATPase GET3 is a ~38 kDa protein. ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. 1. Stefanovic, S. et al. (2007) Cell 128, 1147-59. PMID: 17382883 | ||||||||
| 注意事項 | For research use only. |
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