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| カタログ番号 | HC425014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GFPT1 Polyclonal Antibody (HC425014) is a rabbit polyclonal antibody detecting GFPT1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GFPT1 (Ser341-Gly683). | ||||||||
| ターゲット | Glutamine:fructose-6-phosphate amidotransferase 1, GFAT 1, Hexosephosphate aminotransferase 1, D-fructose-6-phosphate amidotransferase 1, GFPT1, GFPT, GFAT, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, GFAT1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q06210 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) is a ~78 kDa protein. Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway. Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop. Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling. Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation. 1. Ruegenberg, S. et al. (2020) Nature communications 11, 687. PMID: 32019926 2. Kroef, V. et al. (2022) eLife 11. PMID: 35229715 3. Oikari, S. et al. (2016) Glycobiology 26, 710-22. PMID: 26887390 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-GFPT1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
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