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| カタログ番号 | HT422014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GFRA2 Polyclonal Antibody (HT422014) is a rabbit polyclonal antibody detecting GFRA2 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GFRA2 (Asp226-Ser444). | ||||||||
| ターゲット | TGF-beta-related neurotrophic factor receptor 2, RETL2, GDNFR-alpha-2, GFRA2, GFR-alpha-2, Neurturin receptor alpha, TRNR2, GDNF receptor beta, GDNF family receptor alpha-2, NRTNR-alpha, RET ligand 2, NTNR-alpha, GDNFRB, GDNF receptor alpha-2, GDNFR-beta | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00451 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | GDNF family receptor alpha-2 (GFRA2) is a ~51 kDa protein. Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. 1. Cik, M. et al. (2000) The Journal of biological chemistry 275, 27505-12. PMID: 10829012 2. Sandmark, J. et al. (2018) The Journal of biological chemistry 293, 5492-5508. PMID: 29414779 3. Li, J. et al. (2019) eLife 8. PMID: 31535977 4. Baloh, RH. et al. (1997) Neuron 18, 793-802. PMID: 9182803 | ||||||||
| 注意事項 | For research use only. |
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