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Anti-Human GLRA1 Polyclonal Antibody (HB788014)

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Aperçu
Numéro de catalogueHB788014
Description
Anti-Human GLRA1 Polyclonal Antibody (HB788014) is a rabbit polyclonal antibody detecting GLRA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human GLRA1 (Ala32-Gln247).
Cible Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, Glycine receptor subunit alpha-1, GLRA1
Purification Purified by antigen affinity column.
Numéro d'accès P23415
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Glycine receptor subunit alpha-1 (GLRA1) is a ~52 kDa protein. Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol.

1. Mohammadi, B. et al. (2003) European biophysics journal : EBJ 32, 529-36. PMID: 14551753
2. Mowrey, DD. et al. (2013) Structure (London, England : 1993) 21, 1897-904. PMID: 23994010
3. Moraga-Cid, G. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 2865-70. PMID: 25730860
4. Liu, X. et al. (2023) Nature communications 14, 6377. PMID: 37821459
5. Shiang, R. et al. (1993) Nature genetics 5, 351-8. PMID: 8298642
6. Lynch, JW. et al. (1997) The EMBO journal 16, 110-20. PMID: 9009272
7. Zhang, Y. et al. (2015) Neuropharmacology 89, 391-7. PMID: 25445488
8. Horani, S. et al. (2015) Alcoholism, clinical and experimental research 39, 962-8. PMID: 25973519
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human GLRA1 Polyclonal Antibody

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