Anti-Human GNAQ Polyclonal Antibody (HW752014)

Name: Anti-Human GNAQ Polyclonal Antibody
Brand: abinScience
SKU: HW752014
Price: 96 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HW752014

Description

Anti-Human GNAQ Polyclonal Antibody (HW752014) is a rabbit polyclonal antibody detecting GNAQ in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human GNAQ (Met1-Val359).

Cible

GNAQ, GAQ, Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q

Purification

Purified by antigen affinity column.

Numéro d'accès

P50148

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) is a ~42 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins.

1. Zhang, X. et al. (2021) Nature chemical biology 17, 1230-1237. PMID: 34556863

2. Ding, Y. et al. (2022) Cell discovery 8, 55. PMID: 35672283

3. Falzone, ME. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2315011120. PMID: 37991948

4. Alvarez-Curto, E. et al. (2016) The Journal of biological chemistry 291, 27147-27159. PMID: 27852822

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-GNAQ polyclonal antibody at 1μg/ml on various samples.
Lane 1: Jurkat cell lysate
Lane 2: Mouse brain lysate
Lane 3: Mouse cerebellum lysate
Lane 4: Mouse lung lysate
Lane 5: Rat brain lysate
Lane 6: Rat cerebellum lysate
Lane 7: Rat lung lysate

Reférences

Fiche technique

Anti-Human GNAQ Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human GNAQ Polyclonal Antibody (HW752014)

Aperçu

Images

Reférences

Fiche technique

SDS