中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HW339014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GNPDA1 Polyclonal Antibody (HW339014) is a rabbit polyclonal antibody detecting GNPDA1 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GNPDA1 (Met1-Asp289). | ||||||||
| ターゲット | GNPDA1, GlcN6P deaminase 1, Glucosamine-6-phosphate deaminase 1, GNPI, GNPDA 1, Oscillin, KIAA0060, HLN, Glucosamine-6-phosphate isomerase 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P46926 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glucosamine-6-phosphate deaminase 1 (GNPDA1) is a ~32 kDa protein. Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. 1. Alvarez-Añorve, LI. et al. (2011) Biochimica et biophysica acta 1814, 1846-53. PMID: 21807125 2. Oikari, S. et al. (2016) Glycobiology 26, 710-22. PMID: 26887390 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-GNPDA1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: U87 cell lysate
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
