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Anti-Human GPBAR1 Polyclonal Antibody (HA179014)

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Aperçu
Numéro de catalogueHA179014
Description
Anti-Human GPBAR1 Polyclonal Antibody (HA179014) is a rabbit polyclonal antibody detecting GPBAR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human GPBAR1.
Cible G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37, GPBAR1, TGR5
Purification Purified by antigen affinity column.
Numéro d'accès Q8TDU6
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

G-protein coupled bile acid receptor 1 (GPBAR1) is a ~35 kDa protein. G protein-coupled receptor for bile acid. Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order. Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation.

1. Maruyama, T. et al. (2002) Biochemical and biophysical research communications 298, 714-9. PMID: 12419312
2. Kawamata, Y. et al. (2003) The Journal of biological chemistry 278, 9435-40. PMID: 12524422
3. Yang, F. et al. (2020) Nature 587, 499-504. PMID: 32698187
4. Chen, G. et al. (2020) Signal transduction and targeted therapy 5, 142. PMID: 32747649
5. Ma, L. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2117054119. PMID: 35858343
Note For research use only.
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Reférences
Fiche technique
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human GPBAR1 Polyclonal Antibody

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