Anti-Human GPBAR1 Polyclonal Antibody (HA179014)

Name: Anti-Human GPBAR1 Polyclonal Antibody
Brand: abinScience
SKU: HA179014
Price: 168 USD
Availability: InStock

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Каталожный номер

HA179014

Описание

Anti-Human GPBAR1 Polyclonal Antibody (HA179014) is a rabbit polyclonal antibody detecting GPBAR1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human GPBAR1.

Цель

G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37, GPBAR1, TGR5

Очистка

Purified by antigen affinity column.

Номер доступа

Q8TDU6

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

G-protein coupled bile acid receptor 1 (GPBAR1) is a ~35 kDa protein. G protein-coupled receptor for bile acid. Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order. Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation.

1. Maruyama, T. et al. (2002) Biochemical and biophysical research communications 298, 714-9. PMID: 12419312

2. Kawamata, Y. et al. (2003) The Journal of biological chemistry 278, 9435-40. PMID: 12524422

3. Yang, F. et al. (2020) Nature 587, 499-504. PMID: 32698187

4. Chen, G. et al. (2020) Signal transduction and targeted therapy 5, 142. PMID: 32747649

5. Ma, L. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2117054119. PMID: 35858343

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human GPBAR1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human GPBAR1 Polyclonal Antibody (HA179014)

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