Anti-Human Glypican 3 Recombinant Antibody (SAA0134), APC (HW310137)

Name: Anti-Human Glypican 3 Recombinant Antibody (SAA0134), APC
Brand: abinScience
SKU: HW310137
Price: 290 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HW310137
種反応性	Human
アプリケーション	ELISA, FCM, WB
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	SAA0134
抱合	APC
ターゲット	GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
アクセッション番号	P51654
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Glypican-3 (GPC3/Glypican 3) is a ~65 kDa protein. Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. 1. De Cat, B. et al. (2003) The Journal of cell biology 163, 625-35. PMID: 14610063 2. Capurro, MI. et al. (2005) The Journal of biological chemistry 280, 41201-6. PMID: 16227623 3. Capurro, M. et al. (2014) Journal of cell science 127, 1565-75. PMID: 24496449 4. Davoodi, J. et al. (2007) Proteomics 7, 2300-10. PMID: 17549790
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.