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| カタログ番号 | HD559014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human GPR15LG Polyclonal Antibody (HD559014) is a rabbit polyclonal antibody detecting Protein GPR15LG. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GPR15LG (Lys25-Val82). | ||||||||
| ターゲット | AP-57, Antimicrobial peptide with 57 amino acid residues, Antimicrobial peptide-57, C10orf99, CSBF, Colon-derived SUSD2 binding factor, GPR15L, GPR15LG, Protein GPR15 ligand, Protein GPR15L, Protein GPR15LG, Secreted protein C10orf99 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6UWK7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Protein GPR15LG is a ~9 kDa protein. Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation. 1. Suply, T. et al. (2017) Science signaling 10. PMID: 28900043 2. Ocón, B. et al. (2017) Frontiers in immunology 8, 1111. PMID: 28936214 3. Pan, W. et al. (2014) Scientific reports 4, 6812. PMID: 25351403 4. Chen, C. et al. (2018) Scientific reports 8, 8590. PMID: 29872130 5. Tseng, PY. et al. (2022) Science advances 8, eabm7342. PMID: 35704588 | ||||||||
| 注意事項 | For research use only |
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