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| カタログ番号 | HC465014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GRIN1/NMDAR1 (Asp23-His371). | ||||||||
| ターゲット | N-methyl-D-aspartate receptor subunit NR1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic, NMDA 1, NMD-R1, GRIN1, NMDAR1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q05586 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glutamate receptor ionotropic, NMDA 1 (GRIN1/NMDAR1) is a ~105 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Hamdan, FF. et al. (2011) American journal of human genetics 88, 306-16. PMID: 21376300 2. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626 3. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761 4. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851 5. Chen, W. et al. (2017) Journal of human genetics 62, 589-597. PMID: 28228639 6. Zhang, J. et al. (2023) Nature structural & molecular biology 30, 629-639. PMID: 36959261 7. Karp, SJ. et al. (1993) The Journal of biological chemistry 268, 3728-33. PMID: 7679115 8. Younkin, DP. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2174-8. PMID: 7681588 9. Planells-Cases, R. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 5057-61. PMID: 7685113 | ||||||||
| 注意事項 | For research use only. |
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