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| カタログ番号 | HY202014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human H2AB1 Polyclonal Antibody (HY202014) is a rabbit polyclonal antibody detecting H2AB1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human H2AB1 (Met1-Asp115). | ||||||||
| ターゲット | Histone H2A-Bbd type 1, H2A Barr body-deficient, H2A.B, H2A.Bbd, H2AB1, H2AFB1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P0C5Y9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Histone H2A-Bbd type 1 (H2AB1) is a ~12 kDa protein. Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. 1. Tolstorukov, MY. et al. (2012) Molecular cell 47, 596-607. PMID: 22795134 2. Bao, Y. et al. (2004) The EMBO journal 23, 3314-24. PMID: 15257289 3. Okuwaki, M. et al. (2005) Molecular and cellular biology 25, 10639-51. PMID: 16287874 4. Doyen, CM. et al. (2006) The EMBO journal 25, 4234-44. PMID: 16957777 5. Menoni, H. et al. (2007) Molecular and cellular biology 27, 5949-56. PMID: 17591702 6. Eirín-López, JM. et al. (2008) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22, 316-26. PMID: 17726088 7. González-Romero, R. et al. (2008) Gene 413, 1-7. PMID: 18329190 | ||||||||
| 注意事項 | For research use only. |
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