

| Каталожный номер | HY202014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human H2AB1 Polyclonal Antibody (HY202014) is a rabbit polyclonal antibody detecting H2AB1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human H2AB1 (Met1-Asp115). | ||||||||
| Цель | Histone H2A-Bbd type 1, H2A Barr body-deficient, H2A.B, H2A.Bbd, H2AB1, H2AFB1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P0C5Y9 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Histone H2A-Bbd type 1 (H2AB1) is a ~12 kDa protein. Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. 1. Tolstorukov, MY. et al. (2012) Molecular cell 47, 596-607. PMID: 22795134 2. Bao, Y. et al. (2004) The EMBO journal 23, 3314-24. PMID: 15257289 3. Okuwaki, M. et al. (2005) Molecular and cellular biology 25, 10639-51. PMID: 16287874 4. Doyen, CM. et al. (2006) The EMBO journal 25, 4234-44. PMID: 16957777 5. Menoni, H. et al. (2007) Molecular and cellular biology 27, 5949-56. PMID: 17591702 6. Eirín-López, JM. et al. (2008) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22, 316-26. PMID: 17726088 7. González-Romero, R. et al. (2008) Gene 413, 1-7. PMID: 18329190 | ||||||||
| Примечание | For research use only. |
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