Anti-Human HACE1 IP Recombinant Antibody (SAA0202) (HP555013)

Name: Anti-Human HACE1 IP Recombinant Antibody (SAA0202)
Brand: abinScience
SKU: HP555013
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP555013

Reactividad de especies

Human

Aplicaciones

ELISA, IF, IP

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG1

ID de clon

SAA0202

Objetivo

HECT-type E3 ubiquitin transferase HACE1, HACE1, E3 ubiquitin-protein ligase HACE1, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, KIAA1320

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q8IYU2

RRID

Anti-Human HACE1 IP Antibody (SAA0202) (abinScience Cat# HP555013, RRID:AB_3729736)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

E3 ubiquitin-protein ligase HACE1 is a ~102 kDa protein. E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

1. Anglesio, MS. et al. (2004) Human molecular genetics 13, 2061-74. PMID: 15254018

2. Tang, D. et al. (2011) Nature communications 2, 501. PMID: 21988917

3. Torrino, S. et al. (2011) Developmental cell 21, 959-65. PMID: 22036506

4. Singh, S. et al. (2023) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10, e2207672. PMID: 37537642

5. Düring, J. et al. (2024) Nature structural & molecular biology 31, 364-377. PMID: 38332367

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human HACE1 IP Antibody (SAA0202)

Referencias

Datasheet

Anti-Human HACE1 IP Recombinant Antibody (SAA0202).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo