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| カタログ番号 | HP555013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1 | ||||
| クローンID | SAA0202 | ||||
| ターゲット | HECT-type E3 ubiquitin transferase HACE1, HACE1, E3 ubiquitin-protein ligase HACE1, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, KIAA1320 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q8IYU2 | ||||
| RRID | Anti-Human HACE1 IP Antibody (SAA0202) (abinScience Cat# HP555013, RRID:AB_3729736) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | E3 ubiquitin-protein ligase HACE1 is a ~102 kDa protein. E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. 1. Anglesio, MS. et al. (2004) Human molecular genetics 13, 2061-74. PMID: 15254018 2. Tang, D. et al. (2011) Nature communications 2, 501. PMID: 21988917 3. Torrino, S. et al. (2011) Developmental cell 21, 959-65. PMID: 22036506 4. Singh, S. et al. (2023) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10, e2207672. PMID: 37537642 5. Düring, J. et al. (2024) Nature structural & molecular biology 31, 364-377. PMID: 38332367 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human HACE1 IP Antibody (SAA0202)
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