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| カタログ番号 | HP453014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HBS1L (Gly257-Lys478). | ||||||||
| ターゲット | HBS1L, KIAA1038, ERFS, HBS1, HBS1-like protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y450 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | HBS1-like protein (HBS1L) is a ~75 kDa protein. GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. 1. Pisareva, VP. et al. (2011) The EMBO journal 30, 1804-17. PMID: 21448132 2. Saito, S. et al. (2013) The Journal of biological chemistry 288, 17832-43. PMID: 23667253 3. Shao, S. et al. (2016) Cell 167, 1229-1240.e15. PMID: 27863242 4. Zinoviev, A. et al. (2020) Molecular cell 77, 1340-1349.e6. PMID: 32006463 | ||||||||
| 注意事項 | For research use only. |
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