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Anti-Human HDGFL2 Recombinant Nanobody (SAA2783) (HA200013)

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Vista general
Número de catálogoHA200013
Descripción
Anti-Human HDGFL2 Nanobody (SAA2783) (HA200013) is a alpaca monoclonal antibody detecting HDGFL2. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA
Especie huéspedAlpaca
ClonalidadMonoclonal
IsotipoVHH-His
ID de clonSAA2783
Objetivo HDGF-2, HDGF-related protein 2, HDGF2, HDGFL2, HDGFRP2, HRP-2, HRP2, Hepatoma-derived growth factor 2, Hepatoma-derived growth factor-related protein 2
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Purified by Nickel column.
Número de acceso Q7Z4V5
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Hepatoma-derived growth factor-related protein 2 (HDGFL2) is a ~74 kDa protein. Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression.

1. Zhu, X. et al. (2020) Nucleic acids research 48, 6563-6582. PMID: 32459350
2. Baude, A. et al. (2016) Nucleic acids research 44, 2214-26. PMID: 26721387
3. Gao, K. et al. (2015) Biochemical and biophysical research communications 458, 849-55. PMID: 25689719
Nota For research use only.
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human HDGFL2 Recombinant Nanobody (SAA2783)

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