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Anti-Human HELLS Polyclonal Antibody (HV401014)

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Aperçu
Numéro de catalogueHV401014
Description
Anti-Human HELLS Polyclonal Antibody (HV401014) is a rabbit polyclonal antibody detecting HELLS in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human HELLS (Asp523-His748).
Cible PASG, Lymphoid-specific helicase, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, SMARCA6, HELLS, Proliferation-associated SNF2-like protein
Purification Purified by antigen affinity column.
Numéro d'accès Q9NRZ9
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Lymphoid-specific helicase (HELLS) is a ~97 kDa protein. ATP-dependent chromatin remodeler that regulates chromatin accessibility, DNA methylation, and histone modifications. It facilitates de novo DNA methylation at repetitive sequences and promotes transcriptional silencing via recruitment of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), contributing to heterochromatin formation and repression of transposable elements. Also involved in DNA repair by recruiting DNA damage response mediators to double-strand breaks in heterochromatin, promoting homologous recombination via RBBP8/CtIP-dependent end resection. During meiosis, it is recruited by PRDM9 to recombination hotspots, aiding chromatin opening. Through these diverse roles, is crucial for processes such as development, differentiation, and genomic stability.

1. Unoki, M. et al. (2019) The Journal of clinical investigation 129, 78-92. PMID: 30307408
2. Burrage, J. et al. (2012) Journal of cell science 125, 5524-34. PMID: 22946062
3. Kollárovič, G. et al. (2020) Nucleic acids research 48, 1872-1885. PMID: 31802118
4. Spruce, C. et al. (2020) Genes & development 34, 398-412. PMID: 32001511
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human HELLS Polyclonal Antibody

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