

| Каталожный номер | HV401014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human HELLS Polyclonal Antibody (HV401014) is a rabbit polyclonal antibody detecting HELLS in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human HELLS (Asp523-His748). | ||||||||
| Цель | PASG, Lymphoid-specific helicase, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, SMARCA6, HELLS, Proliferation-associated SNF2-like protein | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9NRZ9 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Lymphoid-specific helicase (HELLS) is a ~97 kDa protein. ATP-dependent chromatin remodeler that regulates chromatin accessibility, DNA methylation, and histone modifications. It facilitates de novo DNA methylation at repetitive sequences and promotes transcriptional silencing via recruitment of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), contributing to heterochromatin formation and repression of transposable elements. Also involved in DNA repair by recruiting DNA damage response mediators to double-strand breaks in heterochromatin, promoting homologous recombination via RBBP8/CtIP-dependent end resection. During meiosis, it is recruited by PRDM9 to recombination hotspots, aiding chromatin opening. Through these diverse roles, is crucial for processes such as development, differentiation, and genomic stability. 1. Unoki, M. et al. (2019) The Journal of clinical investigation 129, 78-92. PMID: 30307408 2. Burrage, J. et al. (2012) Journal of cell science 125, 5524-34. PMID: 22946062 3. Kollárovič, G. et al. (2020) Nucleic acids research 48, 1872-1885. PMID: 31802118 4. Spruce, C. et al. (2020) Genes & development 34, 398-412. PMID: 32001511 | ||||||||
| Примечание | For research use only. |
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