中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HM814117 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | H4H2 |
| 抱合 | FITC |
| ターゲット | HLA-B, HLA class I histocompatibility antigen, B alpha chain, Human leukocyte antigen B, HLAB, HLA-B*27 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), FITC |
| アクセッション番号 | P01889 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | HLA class I histocompatibility antigen, B alpha chain (HLA-B*27) is a ~40 kDa protein. Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome. 1. Schmidt, J. et al. (2012) PLoS pathogens 8, e1003042. PMID: 23209413 2. Kløverpris, HN. et al. (2015) Retrovirology 12, 20. PMID: 25808313 3. Chan, KF. et al. (2018) Nature communications 9, 1026. PMID: 29531227 4. Peh, CA. et al. (1998) Immunity 8, 531-42. PMID: 9620674 5. Hillen, N. et al. (2008) European journal of immunology 38, 2993-3003. PMID: 18991276 6. Barber, LD. et al. (1995) Current biology : CB 5, 179-90. PMID: 7743181 7. Motozono, C. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 3428-34. PMID: 24600035 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
