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Anti-Human HLA-DRA*01 Polyclonal Antibody (HM812014)

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Anti-Human HLA-DRA*01 Polyclonal Antibody
Anti-Human HLA-DRA*01 Polyclonal Antibody
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Vista general
Número de catálogoHM812014
Descripción
Anti-Human HLA-DRA*01 Polyclonal Antibody (HM812014) is a rabbit polyclonal antibody detecting HLA-DRA in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human HLA-DRA (Ile26-Phe205).
Objetivo major histocompatibility complex, class II, DR alpha, isoform CRA_a, HLA-DRA
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >95% as determined by SDS-PAGE.
Purificación Purified by antigen affinity column.
Número de acceso P01903
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a ~28 kDa protein. An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins.

1. Shams, H. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 1966-77. PMID: 15265931
2. Röhn, TA. et al. (2004) Nature immunology 5, 909-18. PMID: 15322540
3. Deng, L. et al. (2007) Nature immunology 8, 398-408. PMID: 17334368
4. Kwok, WW. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 2537-44. PMID: 22327072
5. Scally, SW. et al. (2013) The Journal of experimental medicine 210, 2569-82. PMID: 24190431
6. Muehling, LM. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 197, 3214-3224. PMID: 27591323
7. Galperin, M. et al. (2018) Science immunology 3. PMID: 29884618
8. Abelin, JG. et al. (2019) Immunity 51, 766-779.e17. PMID: 31495665
9. Stern, LJ. et al. (1994) Nature 368, 215-21. PMID: 8145819
10. Kropshofer, H. et al. (1997) Immunity 6, 293-302. PMID: 9075930
Nota For research use only.
Imágenes
  • Anti-Human HLA-DRA*01 Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-HLA-DRA polyclonal antibody at 1ug/mL on various samples.
    Lane 1: Daudi cell lysate
    Lane 2: Raji cell lysate

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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