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| カタログ番号 | HM831014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HLA-F (Gly22-Pro304). | ||||||||
| ターゲット | Leukocyte antigen F, CDA12, MHC class I antigen F, HLA F antigen, HLA-F, HLAF, HLA class I histocompatibility antigen, alpha chain F, HLA-5.4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P30511 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | HLA class I histocompatibility antigen, alpha chain F (HLA-F) is a ~39 kDa protein. Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors. 1. Dulberger, CL. et al. (2017) Immunity 46, 1018-1029.e7. PMID: 28636952 2. Garcia-Beltran, WF. et al. (2016) Nature immunology 17, 1067-74. PMID: 27455421 3. Goodridge, JP. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 3553-62. PMID: 24018270 4. Goodridge, JP. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 1567-77. PMID: 23851683 5. Song, S. et al. (2016) Nature medicine 22, 397-403. PMID: 26928464 | ||||||||
| 注意事項 | For research use only. |
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