Anti-Human HMGB1 Recombinant Antibody (SAA2339) (HY200023)

Name: Anti-Human HMGB1 Recombinant Antibody (SAA2339)
Brand: abinScience
SKU: HY200023
Price: 126 USD
Availability: InStock

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Spécification :

20ug
50ug
100ug
1mg

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HY200023

Marque

abinScience

Reactivité des espèces

Human, Bovine

Applications

ELISA, WB

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA2339

Cible

High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1, HMG1

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P09429, P10103

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy.

1. Wei, J. et al. (2021) Cell 184, 76-91.e13. PMID: 33147444

2. Avgousti, DC. et al. (2016) Nature 535, 173-7. PMID: 27362237

3. Wang, G. et al. (2021) Cell death discovery 7, 337. PMID: 34743181

4. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148

5. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706

6. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764

7. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472

8. Min, HJ. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1797-806. PMID: 23303669

9. Lee, LC. et al. (2014) PloS one 9, e115809. PMID: 25549101

Note

For research use only

Images

SDS-PAGE

SDS-PAGE for Anti-Human HMGB1 Antibody (SAA2339)

Reférences

Fiche technique

Anti-Human HMGB1 Recombinant Antibody (SAA2339).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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