Anti-Human HMGB1 Recombinant Antibody (SAA2339) (HY200023)

Name: Anti-Human HMGB1 Recombinant Antibody (SAA2339)
Brand: abinScience
SKU: HY200023
Price: 126 USD
Availability: InStock

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Спецификация:

20ug
50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HY200023

Бренд

abinScience

Реактивность видов

Human, Bovine

Применения

ELISA, WB

Хозяинский вид

Mouse

Клоональность

Monoclonal

Изотип

IgG2a, kappa

ID клона

SAA2339

Цель

High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1, HMG1

Уровень эндотоксинов

< 10 EU/mg

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P09429, P10103

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy.

1. Wei, J. et al. (2021) Cell 184, 76-91.e13. PMID: 33147444

2. Avgousti, DC. et al. (2016) Nature 535, 173-7. PMID: 27362237

3. Wang, G. et al. (2021) Cell death discovery 7, 337. PMID: 34743181

4. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148

5. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706

6. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764

7. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472

8. Min, HJ. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1797-806. PMID: 23303669

9. Lee, LC. et al. (2014) PloS one 9, e115809. PMID: 25549101

Примечание

For research use only

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human HMGB1 Antibody (SAA2339)

Ссылки

Даташит

Anti-Human HMGB1 Recombinant Antibody (SAA2339).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

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