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| カタログ番号 | HY366014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human HNRNPC Polyclonal Antibody (HY366014) is a rabbit polyclonal antibody detecting HNRNPC in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HNRNPC (Ser16-Ala85). | ||||||||
| ターゲット | Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, HNRNPC, HNRPC | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P07910 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) is a ~33 kDa protein. Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. 1. Huang, M. et al. (1994) Molecular and cellular biology 14, 518-33. PMID: 8264621 2. Kim, JH. et al. (2003) Molecular and cellular biology 23, 708-20. PMID: 12509468 3. Shetty, S. (2005) Molecular and cellular biochemistry 272, 107-18. PMID: 16010978 4. Sébillon, P. et al. (1995) Nucleic acids research 23, 3419-25. PMID: 7567451 5. Liu, N. et al. (2015) Nature 518, 560-4. PMID: 25719671 | ||||||||
| 注意事項 | For research use only. |
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