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| カタログ番号 | HB914014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human HNRNPL Polyclonal Antibody (HB914014) is a rabbit polyclonal antibody detecting HNRNPL in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HNRNPL (Ser381-Ser589). | ||||||||
| ターゲット | hnRNP L, HNRPL, Heterogeneous nuclear ribonucleoprotein L, HNRNPL | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P14866 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Heterogeneous nuclear ribonucleoprotein L (HNRNPL) is a ~64 kDa protein. Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. 1. Kuninger, DT. et al. (2002) Nucleic acids research 30, 823-9. PMID: 11809897 2. Liu, G. et al. (2012) The Journal of biological chemistry 287, 22709-16. PMID: 22570490 3. Shankarling, G. et al. (2014) Molecular and cellular biology 34, 71-83. PMID: 24164894 4. Loh, TJ. et al. (2015) Biochimica et biophysica acta 1849, 743-50. PMID: 25623890 5. Blatter, M. et al. (2015) Journal of molecular biology 427, 3001-22. PMID: 26051023 6. Piñol-Roma, S. et al. (1989) The Journal of cell biology 109, 2575-87. PMID: 2687284 7. Hollensen, AK. et al. (2020) eLife 9. PMID: 33174841 | ||||||||
| 注意事項 | For research use only. |
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