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| カタログ番号 | HX893014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HNRNPU (Asp296-Lys462). | ||||||||
| ターゲット | C1orf199, GRIP120, pp120, Scaffold-attachment factor A, p120, SAFA, Nuclear p120 ribonucleoprotein, hnRNP U, SAF-A, Heterogeneous nuclear ribonucleoprotein U, HNRNPU, HNRPU, U21.1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q00839 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Heterogeneous nuclear ribonucleoprotein U (HNRNPU) is a ~90 kDa protein. DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation. Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. 1. Kim, MK. et al. (1999) Molecular and cellular biology 19, 6833-44. PMID: 10490622 2. Fu, D. et al. (2007) Molecular cell 28, 773-85. PMID: 18082603 3. Weidensdorfer, D. et al. (2009) RNA (New York, N.Y.) 15, 104-15. PMID: 19029303 4. Xiao, R. et al. (2012) Molecular cell 45, 656-68. PMID: 22325991 5. Douglas, P. et al. (2015) Molecular and cellular biology 35, 2699-713. PMID: 25986610 6. Nozawa, RS. et al. (2017) Cell 169, 1214-1227.e18. PMID: 28622508 7. Romig, H. et al. (1992) The EMBO journal 11, 3431-40. PMID: 1324173 8. Fackelmayer, FO. et al. (1994) European journal of biochemistry 221, 749-57. PMID: 8174554 | ||||||||
| 注意事項 | For research use only. |
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