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Anti-Human HTR6 Polyclonal Antibody (HA663014)

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Vista general
Número de catálogoHA663014
Descripción
Anti-Human HTR6 Polyclonal Antibody (HA663014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human HTR6 (Pro321-Asn440).
Objetivo 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P50406
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

5-hydroxytryptamine receptor 6 (HTR6) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity.

1. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614
2. He, L. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2209917120. PMID: 36989299
3. Pei, Y. et al. (2023) Biochemical and biophysical research communications 671, 327-334. PMID: 37327704
4. Kohen, R. et al. (1996) Journal of neurochemistry 66, 47-56. PMID: 8522988
5. Meffre, J. et al. (2012) EMBO molecular medicine 4, 1043-56. PMID: 23027611
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human HTR6 Polyclonal Antibody

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