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Обзор
Каталожный номерHA663014
Описание
Anti-Human HTR6 Polyclonal Antibody (HA663014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Реактивность видовHuman
ПримененияELISA, IHC, WB
Хозяинский видRabbit
КлоональностьPolyclonal
ИзотипIgG
Иммуноген E. coli - derived recombinant human HTR6 (Pro321-Asn440).
Цель 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6
Уровень эндотоксинов Please contact with the lab for this information.
Очистка Purified by antigen affinity column.
Номер доступа P50406
Форма Liquid
Буфер хранения 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта
Применение Разбавление
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

5-hydroxytryptamine receptor 6 (HTR6) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity.

1. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614
2. He, L. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2209917120. PMID: 36989299
3. Pei, Y. et al. (2023) Biochemical and biophysical research communications 671, 327-334. PMID: 37327704
4. Kohen, R. et al. (1996) Journal of neurochemistry 66, 47-56. PMID: 8522988
5. Meffre, J. et al. (2012) EMBO molecular medicine 4, 1043-56. PMID: 23027611
Примечание For research use only
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Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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