

| Каталожный номер | HA663014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human HTR6 Polyclonal Antibody (HA663014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant human HTR6 (Pro321-Asn440). | ||||||||
| Цель | 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P50406 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
||||||||
| Информация об использовании продукта |
| ||||||||
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | 5-hydroxytryptamine receptor 6 (HTR6) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. 1. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614 2. He, L. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2209917120. PMID: 36989299 3. Pei, Y. et al. (2023) Biochemical and biophysical research communications 671, 327-334. PMID: 37327704 4. Kohen, R. et al. (1996) Journal of neurochemistry 66, 47-56. PMID: 8522988 5. Meffre, J. et al. (2012) EMBO molecular medicine 4, 1043-56. PMID: 23027611 | ||||||||
| Примечание | For research use only |
Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.
Почта: [email protected]
Быстрый доступ
Свяжитесь с нами
+86-027-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский