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| カタログ番号 | HY384013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA2693 | ||||
| ターゲット | ARO1, Aromatase, CYAR, CYP19, CYP19A1, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, EC:1.14.14.14, Estrogen synthase | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P11511 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Aromatase (CYP19A1) is a ~57 kDa protein. A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. 1. Baravalle, R. et al. (2017) The Journal of steroid biochemistry and molecular biology 167, 23-32. PMID: 27702664 2. Corbin, CJ. et al. (1988) Proceedings of the National Academy of Sciences of the United States of America 85, 8948-52. PMID: 2848247 3. Sohl, CD. et al. (2010) The Journal of biological chemistry 285, 17734-43. PMID: 20385561 4. Cheng, Q. et al. (2012) The Journal of biological chemistry 287, 29554-67. PMID: 22773874 | ||||
| 注意事項 | For research use only |
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