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| カタログ番号 | HX050014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IFI35 Polyclonal Antibody (HX050014) is a rabbit polyclonal antibody detecting IFI35 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IFI35 (Ser2-Gly286). | ||||||||
| ターゲット | IFI35, IFP 35, Ifi-35, Interferon-induced 35 kDa protein, IFP35 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P80217 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interferon-induced 35 kDa protein (IFI35) is a ~31 kDa protein. Acts as a signaling pathway regulator involved in innate immune system response. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation. In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production. In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries. Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion. 1. Das, A. et al. (2015) Virology 485, 383-92. PMID: 26342464 2. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465 3. Jian, D. et al. (2018) Acta physiologica (Oxford, England) 223, e13037. PMID: 29350881 4. Zhou, X. et al. (2000) The Journal of biological chemistry 275, 21364-71. PMID: 10779520 5. Chen, J. et al. (2000) The Journal of biological chemistry 275, 36278-84. PMID: 10950963 | ||||||||
| 注意事項 | For research use only. |
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