Anti-Human IFIT1 Polyclonal Antibody (HY426014)

Name: Anti-Human IFIT1 Polyclonal Antibody
Brand: abinScience
SKU: HY426014
Price: 168 USD
Availability: InStock

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50ug
100ug

Número:

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Número de catálogo

HY426014

Descripción

Anti-Human IFIT1 Polyclonal Antibody (HY426014) is a rabbit polyclonal antibody detecting IFIT1 in ELISA, IHC, WB. Suitable for Human and Macaca fascicularis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human IFIT1 (Met1-Pro478).

Objetivo

IFI-56K, G10P1, Interferon-induced protein with tetratricopeptide repeats 1, IFIT-1, IFNAI1, IFIT1, ISG56, IFI56, Interferon-induced 56 kDa protein, P56

Purificación

Purified by antigen affinity column.

Número de acceso

P09914

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Antiviral innate immune response effector IFIT1 is a ~55 kDa protein. Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families.

1. Pichlmair, A. et al. (2011) Nature immunology 12, 624-30. PMID: 21642987

2. Daugherty, MD. et al. (2016) eLife 5. PMID: 27240734

3. Geng, J. et al. (2024) RNA (New York, N.Y.) 30, 1292-1305. PMID: 39009378

4. Abbas, YM. et al. (2013) Nature 494, 60-4. PMID: 23334420

5. Abbas, YM. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2106-E2115. PMID: 28251928

6. Russ, A. et al. (2022) EMBO reports 23, e55648. PMID: 36285486

7. Terenzi, F. et al. (2008) The EMBO journal 27, 3311-21. PMID: 19008854

8. Raychoudhuri, A. et al. (2011) Journal of virology 85, 12881-9. PMID: 21976647

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human IFIT1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human IFIT1 Polyclonal Antibody (HY426014)

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Imágenes

Referencias

Datasheet

SDS