中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY426014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IFIT1 Polyclonal Antibody (HY426014) is a rabbit polyclonal antibody detecting IFIT1 in ELISA, IHC, WB. Suitable for Human and Macaca fascicularis.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IFIT1 (Met1-Pro478). | ||||||||
| ターゲット | IFI-56K, G10P1, Interferon-induced protein with tetratricopeptide repeats 1, IFIT-1, IFNAI1, IFIT1, ISG56, IFI56, Interferon-induced 56 kDa protein, P56 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P09914 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Antiviral innate immune response effector IFIT1 is a ~55 kDa protein. Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families. 1. Pichlmair, A. et al. (2011) Nature immunology 12, 624-30. PMID: 21642987 2. Daugherty, MD. et al. (2016) eLife 5. PMID: 27240734 3. Geng, J. et al. (2024) RNA (New York, N.Y.) 30, 1292-1305. PMID: 39009378 4. Abbas, YM. et al. (2013) Nature 494, 60-4. PMID: 23334420 5. Abbas, YM. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2106-E2115. PMID: 28251928 6. Russ, A. et al. (2022) EMBO reports 23, e55648. PMID: 36285486 7. Terenzi, F. et al. (2008) The EMBO journal 27, 3311-21. PMID: 19008854 8. Raychoudhuri, A. et al. (2011) Journal of virology 85, 12881-9. PMID: 21976647 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
