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| カタログ番号 | HC576014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IFIT5 (Met1-Ile482). | ||||||||
| ターゲット | ISG58, RI58, IFIT-5, P58, Interferon-induced protein with tetratricopeptide repeats 5, IFIT5, Retinoic acid- and interferon-inducible 58 kDa protein, Interferon-induced 58 kDa protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13325 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) is a ~55 kDa protein. Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. 1. Katibah, GE. et al. (2013) Molecular cell 49, 743-50. PMID: 23317505 2. Feng, F. et al. (2013) Cell research 23, 1055-8. PMID: 23774268 3. Katibah, GE. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 12025-30. PMID: 25092312 4. Abbas, YM. et al. (2013) Nature 494, 60-4. PMID: 23334420 5. Zheng, C. et al. (2015) Cellular signalling 27, 2343-54. PMID: 26334375 | ||||||||
| 注意事項 | For research use only. |
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