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| カタログ番号 | HC024014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IFITM1 Polyclonal Antibody (HC024014) is a rabbit polyclonal antibody detecting Interferon-induced transmembrane protein 1; Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD225; IFITM1; CD225; IFI17 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human IFITM1 (His2-His36&Ala58-Asn86&Ser108-Tyr125). | ||||||||
| ターゲット | Interferon-induced transmembrane protein 1; Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD225; IFITM1; CD225; IFI17 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P13164 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interferon-induced transmembrane protein 1 (IFITM1) is a ~13 kDa protein. IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Inhibits SARS-CoV-2 S protein-mediated syncytia formation. 1. Narayana, SK. et al. (2015) The Journal of biological chemistry 290, 25946-59. PMID: 26354436 2. Shi, G. et al. (2021) The EMBO journal 40, e106501. PMID: 33270927 3. Buchrieser, J. et al. (2020) The EMBO journal 39, e106267. PMID: 33051876 | ||||||||
| 注意事項 | For research use only |
Lane 1: Jurkat cell lysate
Lane 2: HepG2 cell lysate
Lane 3: K562 cell lysate
Lane 4: HL-60 cell lysate
Lane 5: Hela cell lysate
Lane 6: 293T cell lysate
Lane 7: NIH3T3 cell lysate
Lane 8: MCF-7 cell lysate
Lane 9: Mouse spleen lysate
Lane 10: Mouse testis lysate
Lane11: Mouse brain lysate
Lane12: Rat spleen lysate
Lane13: Rat testis lysate
Lane14: Rat brain lysate
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