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| カタログ番号 | HW716013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1733 | ||||
| ターゲット | Interferon alpha binding protein, Interferon alpha/beta receptor 2, IFNAR2, IFN-alpha binding protein, IFN-R-2, IFNABR, IFNARB, Type I interferon receptor 2, IFN-alpha/beta receptor 2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P48551 | ||||
| RRID | Anti-Human IFNAR2 Antibody (SAA1733) (abinScience Cat# HW716013, RRID:AB_3727494) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Interferon alpha/beta receptor 2 (IFNAR2) is a ~57 kDa protein. Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. 1. Russell-Harde, D. et al. (1999) Biochemical and biophysical research communications 255, 539-44. PMID: 10049744 2. Piehler, J. et al. (1999) Journal of molecular biology 294, 223-37. PMID: 10556041 3. Thomas, C. et al. (2011) Cell 146, 621-32. PMID: 21854986 4. Duncan, CJ. et al. (2015) Science translational medicine 7, 307ra154. PMID: 26424569 5. Arimoto, KI. et al. (2017) Nature structural & molecular biology 24, 279-289. PMID: 28165510 6. Zhang, Q. et al. (2020) Science (New York, N.Y.) 370. PMID: 32972995 7. Domanski, P. et al. (1995) The Journal of biological chemistry 270, 21606-11. PMID: 7665574 8. Novick, D. et al. (1995) Journal of leukocyte biology 57, 712-8. PMID: 7759950 9. Novick, D. et al. (1994) Cell 77, 391-400. PMID: 8181059 10. Platanias, LC. et al. (1996) The Journal of biological chemistry 271, 23630-3. PMID: 8798579 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human IFNAR2 Antibody (SAA1733)
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