Anti-Human IFN-gamma Recombinant Antibody (SAA0266) (HF813013)

Name: Anti-Human IFN-gamma Recombinant Antibody (SAA0266)
Brand: abinScience
SKU: HF813013
Price: 110 USD
Availability: InStock

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20ug
50ug
100ug
1mg

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HF813013

Reactivité des espèces

Human

Applications

ELISA, FCM, Neutralization

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG1, lambda

ID de clone

SAA0266

Cible

Interferon gamma, IFN-gamma, Immune interferon, IFNG, IFN-γ

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P01579

RRID

Anti-Human IFNG/IFN-gamma Antibody (SAA0266) (abinScience Cat# HF813013, RRID:AB_3725386)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Interferon gamma (IFNG/IFN-gamma) is a ~19 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.

1. El Bougrini, J. et al. (2006) Cellular and molecular biology (Noisy-le-Grand, France) 52, 9-15. PMID: 16914093

2. Hisamatsu, H. et al. (1996) The Journal of experimental medicine 183, 1807-16. PMID: 8666937

3. Greenlund, AC. et al. (1993) The Journal of biological chemistry 268, 18103-10. PMID: 8349687

4. Akiyama, K. et al. (1994) FEBS letters 343, 85-8. PMID: 8163024

5. Fabunmi, RP. et al. (2001) Journal of cell science 114, 29-36. PMID: 11112687

6. Lah, TT. et al. (1995) FEBS letters 363, 85-9. PMID: 7729559

Note

For research use only.

Isotype Control

Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

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