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| カタログ番号 | HP142014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IFT20 Polyclonal Antibody (HP142014) is a rabbit polyclonal antibody detecting IFT20 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, Danio rerio, and Xenopus laevis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IFT20 (Met1-Lys132). | ||||||||
| ターゲット | hIFT20, IFT20, Intraflagellar transport protein 20 homolog | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8IY31 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Intraflagellar transport protein 20 homolog (IFT20) is a ~15 kDa protein. Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. 1. Pugacheva, EN. et al. (2007) Cell 129, 1351-63. PMID: 17604723 2. Follit, JA. et al. (2006) Molecular biology of the cell 17, 3781-92. PMID: 16775004 3. Schmid, FM. et al. (2018) The Journal of cell biology 217, 151-161. PMID: 29237719 | ||||||||
| 注意事項 | For research use only. |
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