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Anti-Human IGF2BP1 Polyclonal Antibody (HP412014)

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Anti-Human IGF2BP1 Polyclonal Antibody
Anti-Human IGF2BP1 Polyclonal Antibody
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Vista general
Número de catálogoHP412014
Descripción
Anti-Human IGF2BP1 Polyclonal Antibody (HP412014) is a rabbit polyclonal antibody detecting IGF2BP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Chicken.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human IGF2BP1 (Val194-Asn369).
Objetivo VICKZ family member 1, Zipcode-binding protein 1, IGF2BP1, VICKZ1, Coding region determinant-binding protein, IMP1, IMP-1, ZBP1, IGF-II mRNA-binding protein 1, CRDBP, Insulin-like growth factor 2 mRNA-binding protein 1, ZBP-1, CRD-BP, IGF2 mRNA-binding protein 1
Purificación Purified by antigen affinity column.
Número de acceso Q9NZI8
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is a ~63 kDa protein. RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons.

1. Huang, H. et al. (2018) Nature cell biology 20, 285-295. PMID: 29476152
2. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947
Nota For research use only.
Imágenes
  • Anti-Human IGF2BP1 Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-IGF2BP1 polyclonal antibody at 1μg/ml on various samples.
    Lane 1: K562 cell lysate
    Lane 2: 293T cell lysate

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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